Selected Publications:

Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function.
Free access reprint link
Swamynathan MM, Kuang S, Watrud KE, Doherty MR, Gineste C, Mathew G, Gong GQ, Cox H, Cheng E, Reiss D, Kendall J, Ghosh D, Reczek CR, Zhao X, Herzka T, Špokaitė S, Dessus AN, Kim ST, Klingbeil O, Liu J, Nowak DG, Alsudani H, Wee TL, Park Y, Minicozzi F, Rivera K, Almeida AS, Chang K, Chakrabarty RP, Wilkinson JE, Gimotty PA, Diermeier SD, Egeblad M, Vakoc CR, Locasale JW, Chandel NS, Janowitz T, Hicks JB, Wigler M, Pappin DJ, Williams RL, Cifani P, Tuveson DA, Laporte J, Trotman LC.
Science. 2024 Oct 25;386(6720):eadk9167. doi: 10.1126/science.adk9167. Epub 2024 Oct 25. PMID: 39446948

Next Directions in the Neuroscience of Cancers Arising outside the CNS.
Amit M, Anastasaki C, Dantzer R, Demir IE, Deneen B, Dixon KO, Egeblad M, Gibson EM, Hervey-Jumper SL, Hondermarck H, Magnon C, Monje M, Na'ara S, Pan Y, Repasky EA, Scheff NN, Sloan EK, Talbot S, Tracey KJ, Trotman LC, Valiente M, Van Aelst L, Venkataramani V, Venkatesh HS, Vermeer PD, Winkler F, Wong RJ, Gutmann DH, Borniger JC.
Cancer Discov. 2024 Apr 4;14(4):669-673. doi: 10.1158/2159-8290.CD-23-1495. PMID: 38571430

FABP5 Inhibition against PTEN-Mutant Therapy Resistant Prostate Cancer.
M Swamynathan M, Mathew G, Aziz A, Gordon C, Hillowe A, Wang H, Jhaveri A, Kendall J, Cox H, Giarrizzo M, Azabdaftari G, Rizzo RC, Diermeier SD, Ojima I, Bialkowska AB, Kaczocha M, Trotman LC.
Cancers (Basel). 2023 Dec 21;16(1):60. doi: 10.3390/cancers16010060. PMID: 38201488

Combined whole-organ imaging at single-cell resolution and immunohistochemical analysis of prostate cancer and its liver and brain metastases.
Taranda J, Mathew G, Watrud K, El-Amine N, Lee MF, Elowsky C, Bludova A, Escobar Avelar S, Nowak DG, Wee TL, Wilkinson JE, Trotman LC, Osten P.
Cell Rep. 2021 Nov 16;37(7):110027. doi: 10.1016/j.celrep.2021.110027.PMID: 34788609

Advances in preclinical evaluation of experimental antibody-drug conjugates.
Lyons SK, Plenker D, Trotman LC.
Cancer Drug Resist. 2021.PMID: 34532655

Roadmap for the Emerging Field of Cancer Neuroscience.
Monje M, Borniger JC, D'Silva NJ, Deneen B, Dirks PB, Fattahi F, Frenette PS, Garzia L, Gutmann DH, Hanahan D, Hervey-Jumper SL, Hondermarck H, Hurov JB, Kepecs A, Knox SM, Lloyd AC, Magnon C, Saloman JL, Segal RA, Sloan EK, Sun X, Taylor MD, Tracey KJ, Trotman LC, Tuveson DA, Wang TC, White RA, Winkler F.
Cell. 2020 Apr 16;181(2):219-222. PMID: 32302564

Competence against insufficiency: Why are men mostly safe from a rare and deadly prostate cancer?
Mathew G, Trotman LC.
J Exp Med. 2020 Jun 1;217(6). PMID: 32236496

PTEN: Bridging Endocytosis and Signaling
Lee MF, Trotman LC.
Cold Spring Harb Perspect Med. 9 Dec 2019. PMID: 31818848

The PHLPP2 phosphatase is a druggable driver of prostate cancer progression.
Nowak DG, Katsenelson KC, Watrud KE, Chen M, Mathew G, D'Andrea VD, Lee MF, Swamynathan MM, Casanova-Salas I, Jibilian MC, Buckholtz CL, Ambrico AJ, Pan CH, Wilkinson JE, Newton AC, Trotman LC.
J Cell Biol. 2019 May 15. PMID: 31092557

Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells.
Naguib A, Mathew G, Reczek CR, Watrud K, Ambrico A, Herzka T, Salas IC, Lee MF, El-Amine N, Zheng W, Di Francesco ME, Marszalek JR, Pappin DJ, Chandel NS, Trotman LC.
Cell Rep. 2018 Apr 3;23(1):58-67. doi: 10.1016/j.celrep.2018.03.032. PMID: 29617673

The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.
Chen M, Nowak DG, Narula N, Robinson B, Watrud K, Ambrico A, Herzka TM, Zeeman ME, Minderer M, Zheng W, Ebbesen SH, Plafker KS, Stahlhut C, Wang VM, Wills L, Nasar A, Castillo-Martin M, Cordon-Cardo C, Wilkinson JE, Powers S, Sordella R, Altorki NK, Mittal V, Stiles BM, Plafker SM, Trotman LC.
J Cell Biol. 2017 Mar 6;216(3):641-656. doi: 10.1083/jcb.201604025. Epub 2017 Feb 13. PMID: 28193700

Myc drives Pten/ p53-deficient proliferation and metastasis due to Il6-secretion and Akt-suppression via Phlpp2.
Dawid G. Nowak, Hyejin Cho, Tali Herzka, Kaitlin Watrud, Daniel V. DeMarco, Victoria M.Y. Wang, Serif Senturk, Christof Fellmann, David Ding, Tumas Beinortas, David Kleinman, Muhan Chen, Raffaella Sordella, John E. Wilkinson, Mireia Castillo-Martin, Carlos Cordon-Cardo, Brian D. Robinson & Lloyd C. Trotman.
Cancer Discov. 2015 Mar 31. pii: CD-14-1113. PMID: 25829425

PTEN Functions by Recruitment to Cytoplasmic Vesicles.
Naguib A, Bencze G, Cho H, Zheng W, Tocilj A, Elkayam E, Faehnle CR, Jaber N, Pratt CP, Chen M, Zong WX, Marks MS, Joshua-Tor L, Pappin DJ, Trotman LC.
Molecular Cell. 2015 Apr. PMID: 25866245

Rapid in vivo validation of candidate drivers derived from the PTEN-mutant prostate metastasis genome.
Cho H, Herzka T, Stahlhut C, Watrud K, Robinson BD, Trotman LC.
Methods. 2015 Jan 12. PMID: 25592467

p53 mutations change phosphatidylinositol acyl chain composition.
Naguib A, Bencze G, Engle DD, Chio II, Herzka T, Watrud K, Bencze S, Tuveson DA, Pappin DJ, Trotman LC.
Cell Reports, 2015 Jan 6. PMID: 25543136

RapidCaP, a novel GEM model for analysis and therapy of metastatic prostate cancer reveals Myc as a driver of Pten-mutant metastasis.
Cho H, Herzka T, Zheng W, Qi J, Wilkinson JE, Bradner JE, Robinson BD, Castillo-Martin M, Cordon-Cardo C, Trotman LC.
Cancer Discov. 2014 Jan 20. PMID: 24444712

Prostate Cancer Genetic-susceptibility Locus on Chromosome 20q13 is Amplified and Coupled to Androgen Receptor-regulation in Metastatic Tumors. Labbe, D. P., Nowak, D. G., Deblois, G., Lessard, L., Giguere, V., Trotman, L. C. Tremblay, M. L.
Molecular Cancer Res. 2013 Dec 30. PMID: 24379448.

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia.
Howitt J, Lackovic J, Low LH, Naguib A, Macintyre A, Goh CP, Callaway JK, Hammond V, Thomas T, Dixon M, Putz U, Silke J, Bartlett P, Yang B, Kumar S, Trotman LC, Tan SS.
J Cell Biol. 2012 Jan 2.

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.
Chen, M., Pratt, C. P., Zeeman, M. E., Schultz, N., Taylor, B.S., O’Neill, A., Castillo-Martin, M., Nowak, D. G., Naguib, A., Navin, N., Atwal, G.S., Sander C., Gerald W.L., Cordon-Cardo C., Newton A.C., Carver B.S., Trotman L.C.
Cancer Cell. 2011 Aug 16;20(2):173-86.